are clickable links to medically peer-reviewed studies. Nutrients 2020;12(2):274. View abstract. Am J Epidemiol 1999;149:801-9. JAMA 1994;272:1413-20. A. Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. Diet and lifestyle correlates of lutein in the blood and diet. Invest Ophthalmol.Vis.Sci. View abstract. A., Hollenbach, K. A., Newman, V. A., Faerber, S., Ritenbaugh, C. K., Gold, E., Stefanick, M. L., Jones, L. A., Marshall, J. R., and Pierce, J. P. On the importance of using multiple methods of dietary assessment. Eur.J Clin.Nutr. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. The first 200 years. View abstract. Chew EY, Clemons TE, Agrn E, et al. Exp Eye Res 2004;79:21-27. Hammond BR Jr, Johnson EJ, Russell RM, et al. Bonds DE, Harrington M, Worrall BB, et al. 2006;124(8):1151-1162. Liver Cleanse | Lutein Benefits, Uses, Foods, Side Effects and More - Dr Edwards CG, Walk AM, Thompson SV, et al. View abstract. View abstract. Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. Select a condition to view a list of vitamins. View abstract. Thurmann PA, Schalch W, Aebischer JC, et al. BMC Ophthalmol 2007;7:3. 2012;25(5):523-527. Lutein has earned the nickname the eye vitamin because itswell-known for protecting eye health. Seddon JM, Ajani UA, Sperduto R, et al. Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. 2005;15 Suppl 2:S140-S149. View abstract. Mares-Perlman JA, Brady WE, Klein R, et al. 2007;125(9):1225-1232. Regul.Toxicol Pharmacol 2006;45(3):289-298. Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Flood, V., Rochtchina, E., Wang, J. J., Mitchell, P., and Smith, W. Lutein and zeaxanthin dietary intake and age related macular degeneration. J.Matern.Fetal Neonatal Med. 22. 2000;41(11):3322-3326. J Nutr 1998;128:1920-6.. View abstract. Landrum JT, Bone RA, Joa H, et al. Adackapara, C. A., Sunness, J. S., Dibernardo, C. W., Melia, B. M., and Dagnelie, G. Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial. A., Meyer-Wenger, A., Moser, U., Wright, A., Southon, S., Thurnham, D., Chopra, M., van den, Berg H., Olmedilla, B., Favier, A. E., and Roussel, A. M. No significant effects of lutein, lycopene or beta-carotene supplementation on biological markers of oxidative stress and LDL oxidizability in healthy adult subjects. Effects of supplemental beta-carotene , cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. 2000;41(5):1200-1209. View abstract. Compared to the control group, diabetic rats taking the supplements experienced lower oxidative stress rates and less damage done to the retina of the eyes, despite being under hyperglycemic conditions. Lutein uses and benefits include helping prevent eye conditions like macular degeneration and cataracts, skin disorders and skin cancer, several types of cancer, including colon or breast cancer, type 2 diabetes, and heart disease. Note that the numbers in parentheses (1, 2, etc.) 2002;132(3):525S-530S. Zhang PC, Wu CR, Wang ZL, Wang LY, Han Y, Sun SL, et al. View abstract. Adv Nutr 2021. 2001;42(1):235-240. J Sci Food Agric. View abstract. 2012;96(5):1207S-1213S. Dietary modification of human macular pigment density. Zhou Y, Wang T, Meng Q, Zhai S. Association of carotenoids with risk of gastric cancer: a meta-analysis. Biosci Biotechnol Biochem 2019;83(12):2372-4. Abnet, C. C., Qiao, Y. L., Dawsey, S. M., Buckman, D. W., Yang, C. S., Blot, W. J., Dong, Z. W., Taylor, P. R., and Mark, S. D. Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. 2011;24 Suppl 1:147-150. Am.J.Clin.Nutr. Long-term supplementation with alpha-tocopherol and beta-carotene and age-related cataract. Ophthalmology 2008;115(5):876-883. Xiong K, Zhao Y, Hu S, Ma A, Ma Y. Dose-response relationship between oral lutein intake and plasma lutein concentration: A randomized controlled trial. Gartner, C., Stahl, W., and Sies, H. Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human. View abstract. Mewborn CM, Lindbergh CA, Hammond BR, Renzi-Hammond LM, Miller LS. J Nutr 2022;152(11):2555-64. are clickable links to these studies. Am.J.Clin.Nutr. Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral doses. WebLutein is concentrated in the primate retina, where together with zeaxanthin it forms the macular pigment. View abstract. Juturu V, Bowman JP, Deshpande J. Dietary lutein plus zeaxanthin and choline intake is interactively associated with cognitive flexibility in middle-adulthood in adults with overweight and obesity. Am J Hypertens. 2013;73(2):236-45. Gouado, I., Schweigert, F. J., Ejoh, R. A., Tchouanguep, M. F., and Camp, J. V. Systemic levels of carotenoids from mangoes and papaya consumed in three forms (juice, fresh and dry slice). Arch.Biochem.Biophys. View abstract. Am.J.Ophthalmol. 7-15-2001;391(2):160-164. JAMA Intern Med. Trumbo, P. R. and Ellwood, K. C. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. A dose-response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract. Snellen, E. L., Verbeek, A. L., Van Den Hoogen, G. W., Cruysberg, J. R., and Hoyng, C. B. Neovascular age-related macular degeneration and its relationship to antioxidant intake. Am.J.Clin.Nutr. They are also found in many dark green vegetables; however the large amounts of View abstract. A., de Vries, A. J., Goldbohm, R. A., Tijburg, L. B., Kardinaal, A. F., and van Poppel, G. Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. Acta Ophthalmol. In addition to being found within thepigments of oureyes, carotenoids are also present within the skin. Bahrami, H., Melia, M., and Dagnelie, G. Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289]. Nutrition 2012;28(6):605-610. Lutein and zeaxanthin intake during pregnancy and visual function in offspring at 11-12 years of age. Similarly, other studies show that higher dietary intakes ofzeaxanthin and lutein along with other natural antioxidants, includingvitamin C,beta-caroteneandvitamin E, are associated with a significantly decreased risk of cataract formation. Li J, Abdel-Aal EM. Koonsvitsky BP, Berry DA, et al. Vitamin A and carotenoids and the risk of Parkinson's disease: a systematic review and meta-analysis. Ann Neurol. Association of blood antioxidants and vitamins with risk of age-related cataract: a meta-analysis of observational studies. View abstract. 2002;132(12):3668-3673. 2001;55(4):252-259. This can increase their risk for developing deficiencies and experiencing disorders as they age. Invest Ophthalmol.Vis.Sci. View abstract. Taylor, A., Jacques, P. F., Chylack, L. T., Jr., Hankinson, S. E., Khu, P. M., Rogers, G., Friend, J., Tung, W., Wolfe, J. K., Padhye, N., and Willett, W. C. Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities. View abstract. Central retinal thickness is positively correlated with macular pigment optical density. Mol.Nutr.Food Res. Giordano, P., Scicchitano, P., Locorotondo, M., Mandurino, C., Ricci, G., Carbonara, S., Gesualdo, M., Zito, A., Dachille, A., Caputo, P., Riccardi, R., Frasso, G., Lassandro, G., Di, Mauro A., and Ciccone, M. M. Carotenoids and cardiovascular risk. View abstract. Ophthalmic Res. It may help decrease heart problems. View abstract. J Natl.Cancer Inst. WebThe best antihistamine for eczema is the one that relieves your symptoms. Chen J, Jiang W, Shao L, Zhong D, Wu Y, Cai J. View abstract. The average person who eats the standard American diet is likely running low in this carotenoid, in addition to other important antioxidants. Ito, Y., Wakai, K., Suzuki, K., Tamakoshi, A., Seki, N., Ando, M., Nishino, Y., Kondo, T., Watanabe, Y., Ozasa, K., and Ohno, Y. Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) study. Tan AC, Balaratnasingam C, Yannuzzi LA. Heinrich, U., Gartner, C., Wiebusch, M., Eichler, O., Sies, H., Tronnier, H., and Stahl, W. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. Int J Vitam Nutr Res 1998;68:360-5. WebCommon drugs people take besides Lutein *: Dupixent: 2 people, 18.18%. In addition, reduced For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. 2003;42(6):315-323. The association of plasma micronutrients with the risk of cervical dysplasia in Hawaii. Biomed Res 2011;32(6):387-393. Curr.Eye Res. View abstract. 2006;84(5):971-974. Teikari JM, Rautalahti M, Haukka J, et al. The pharmacological effects of quercetin, such as its antioxidant, anti-inflammatory, antiallergic, antiaging, and anticancer activities, as well as its regulating effect on interleukin (IL)-6, IL-8, tumor necrosis factor (TNF), histamine, and tryptase release in mast cells, are well acknowledged [9]. View abstract. Zinc. Chong, E. W., Wong, T. Y., Kreis, A. J., Simpson, J. Start by eating more lutein-rich, brightly colored fruits, veggies andpasture-raisedeggs. View abstract. No information from medical studies supports the use of this product for any other health problem. Ophthalmology 2001;108(11):1992-1998. View abstract. Olmedilla B, Granado F, Southon S, et al. View abstract. View abstract. 2007;78(5):213-219. Kobayashi J, Tominaga E, Ozeki M, Okubo T, Nakagawa K, Miyazawa T. Randomized controlled trial of a water-soluble formulation of lutein in humans. View abstract. 2004;80(1):131-136. J.Nutr. Int.J.Cancer 9-1-2012;131(5):1158-1168. Food Chem 12-15-2012;135(4):2736-2742. Siems, W. G., Sommerburg, O., and van Kuijk, F. J. Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro. Romagnoli, C., Giannantonio, C., Cota, F., Papacci, P., Vento, G., Valente, E., Purcaro, V., and Costa, S. A prospective, randomized, double blind study comparing lutein to placebo for reducing occurrence and severity of retinopathy of prematurity. Robman, L., Vu, H., Hodge, A., Tikellis, G., Dimitrov, P., McCarty, C., and Guymer, R. Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration. 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