diphenhydramine and lorazepam both increase sedation. 0000001412 00000 n
Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. This drug is available at a middle level co-pay. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and codeine both increase sedation. Use Caution/Monitor. Maintenance: 900-1800 mg/day administered in 3 divided doses; doses of up to 2400 mg/day have been tolerated in long-term clinical studies; up to 3600 mg/day has been tolerated in short-term studies. Initial: 2-3 mg PO q8-12hr PRN; not to exceed 10 mg/day, Maintenance: 2-6 mg/day PO divided q8-12hr, Indicated for anxiety disorders in adults who are receiving stable, evenly divided, TID dosing with lorazepam tablets, Recommended dose: Administer capsule PO qAM; dose equals the total daily dose of previously administered lorazepam tablets, Dosage adjustment: Discontinue Loreev XR and switch to lorazepam tablets to adjust dosage, 0.02-0.06 mg/kg intermittent IV q2-6hr PRN, OR, 0.01-0.1 mg/kg/hr continuous IV; not to exceed 10 mg/hr, IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment or renal failure, IV/IM (prolonged periods or high doses): Monitor; risk of propylene glycol toxicity, PO: No dose adjustment recommended in mild-to-moderate impairment; use with caution (may require lower dose) in severe impairment, IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment of hepatic failure, calcium/magnesium/potassium/sodium oxybates, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death, Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate, Limit dosages and durations to the minimum required, Follow patients for signs and symptoms of respiratory depression and sedation, On September 2020, FDA addressed serious risks of benzodiazepine addiction, abuse, and misuse, which can lead to overdose and death, Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes; before prescribing and throughout treatment, assess each patients risk for abuse, misuse, and addiction, Physical dependence can occur when taken steadily for several days to weeks, even as prescribed, Risks of dependence and withdrawal increase with longer treatment duration and higher daily dose; although injection is indicated only for intermittent use, if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction may precipitate acute withdrawal reactions, including seizures, which can be life-threatening; use gradual taper when discontinuing therapy to reduce withdrawal reactions risk, Assess each patients risk prior to prescribing and monitor regularly for the development of these conditions, Published animal studies demonstrate that administration of anesthetic and sedation drugs that block NMDA receptors and/or potentiate GABA activity increase neuronal apoptosis in developing brain and result in long-term cognitive deficits when used for longer than 3 hours; repeated exposure may also result in negative effects on fetal or young childrens brain development, Caution with use during surgeries or procedures in children younger than 3 yr or in pregnant women during their third trimester, Assess the risk:benefit ratio in these populations, especially for prolonged procedures (ie, >3 hr) or multiple procedures, Prior to use, dilute injection solution with an equal amount of compatible diluent (D5W, NS, SWFI), Administer IV injection slowly, directly into a vein or into tubing of a free-flowing, compatible IV infusion (eg, NS, D5W), at no more than 2 mg/min, Validate patent venous catheter with repeated aspiration during infusion to visualize venous blood return, Inadvertent intra-arterial injection may produce arteriospasm resulting in gangrene, potentially requiring amputation, Rapid IV infusion may result in apnea, bradycardia, hypotension, cardiac arrest, Continuous infusion solutions should have an in-line filter and should be checked frequently for possible precipitation, Emergency resuscitative equipment should be available when administering IV, Capsule may be opened and entire contents sprinkled onto a tablespoon of applesauce, Swallow within 2 hours of mixing; do not store mixture for future use, Drink a glass of water after swallowing mixture, Gradually taper dose to reduce risk of withdrawal reactions, If withdrawal reactions occur, consider pausing the taper or increasing the dosage to the previous tapered dosage level; subsequently decrease dosage more slowly. Profound sedation, respiratory depression, coma, and death may result if coadministered. lorazepam decreases effects of rapacuronium by pharmacodynamic antagonism. Monitor closely for signs of respiratory depression and sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. lurasidone, lorazepam. Enter your username below and we'll send you an email explaining how to change your password. lorazepam and sufentanil both increase sedation. As needed benzodiazepine doses were administered in 38% of encounters post conversion, but escalation of a scheduled enteral benzodiazepine regimen was only required in 2.8% of encounters. gemifloxacin increases levels of lorazepam by decreasing metabolism. Minor (1)lorazepam decreases effects of atracurium by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam and baclofen both increase sedation. In. Seventy-one patient encounters were analyzed (median age, 2.5 yr; interquartile range, 1.25.3). lorazepam and carisoprodol both increase sedation. Anxiolytics: past, present, and future agents. lorazepam and thiothixene both increase sedation. Either increases effects of the other by sedation. Monitor closely for signs of respiratory depression and sedation. xb```i\ cc`a4xq`1 cfLk2^eMab\`Y9N"Nykf46tH h)i:b4Y,Q!a6[CNbaP+" Minor/Significance Unknown. Serious - Use Alternative (1)sufentanil SL, lorazepam. Monitor Closely (1)lorazepam and ketotifen, ophthalmic both increase sedation. Benzodiazepines are a new generation of drugs that almost totally replaced the older type of anti-anxiety drugs, barbiturates. Use Caution/Monitor. Minor (1)lorazepam decreases levels of cyanocobalamin by inhibition of GI absorption. lorazepam and ziconotide both increase sedation. Monitor Closely (1)lorazepam and triazolam both increase sedation. lorazepam increases and phendimetrazine decreases sedation. Monitor Closely (1)lorazepam and protriptyline both increase sedation. lorazepam and methocarbamol both increase sedation. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. lorazepam and quazepam both increase sedation. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Use Caution/Monitor. Our benzo calculator uses the first mentioned and most popular option duration. Use Caution/Monitor. Benzodiazepines, such as lorazepam and midazolam, are frequently administered to surgical intensive care unit (ICU) patients for postoperative sedation. Biotin supplementation may be necessary. lorazepam and shepherd's purse both increase sedation. Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: a prospective, randomized comparison. lorazepam and chlorzoxazone both increase sedation. lorazepam and perphenazine both increase sedation. Monitor Closely (1)pentobarbital and lorazepam both increase sedation. Monitor Closely (1)lorazepam increases and methamphetamine decreases sedation. Patient demographics, benzodiazepine dose escalations, as needed benzodiazepine requirements, and severe adverse events within 48 hours of conversion were assessed. Avoid or Use Alternate Drug. Monitor Closely (1)lorazepam and clomipramine both increase sedation. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Minor (1)lorazepam and eucalyptus both increase sedation. Monitor Closely (1)propofol and lorazepam both increase sedation. lorazepam decreases effects of cisatracurium by pharmacodynamic antagonism. Monitor closely for signs of respiratory depression and sedation. Minor (1)esomeprazole increases levels of lorazepam by decreasing metabolism. Monitor Closely (1)cannabidiol will increase the level or effect of lorazepam by decreasing metabolism. Applies only to oral form of both agents. Minor/Significance Unknown. Use Caution/Monitor. Instead, skip the missed dose. je 8&K`Y/ o *C'lvpeKBg6CK pIE-azD-`[\s2q&o|in(J|6iT1t>aRkDXs(z%7;PS d\c1"4S#8jk*TR78IgnR(kv Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. BZ&Ap^b?UC@60ak 3 0 obj
Effect of interaction is not clear, use caution. Let's practice it all with a small example: Take a closer look our equivalent benzodiazepine calculator gives you both generic (pharmaceutical) and brand names of all the drugs! Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug. Monitor Closely (1)cyproheptadine and lorazepam both increase sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam and nalbuphine both increase sedation. Use Caution/Monitor. Both drugs can cause metabolic acidosis. Minor/Significance Unknown. 1Department of Pharmacy Services, The Childrens Hospital of Philadelphia, Philadelphia, PA. 2Department of Anesthesiology and Critical Care Medicine, The Childrens Hospital of Philadelphia, Philadelphia, PA. Minor/Significance Unknown. Monitor Closely (1)secobarbital and lorazepam both increase sedation. Minor/Significance Unknown. Avoid or Use Alternate Drug. Monitor Closely (1)lorazepam and iloperidone both increase sedation. Monitor Closely (1)lorazepam and chlorpromazine both increase sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Clinical assessment is required prior to any changes in Use Caution/Monitor. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (1)lorazepam increases and methylenedioxymethamphetamine decreases sedation. Minor (1)rifabutin decreases levels of lorazepam by increasing metabolism. .2/ZfG[:{oH}ZJUmniOF F.\6K"abU:hiVyz6gAKt_|pgrqx9MUWz,_LgMvU ?>MJx
'A7 gk\nd^=zff3plgZn7GL:nnL0R2 \mSKu-08W}yx8m}R,Q3}Mm