Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma(Table 319). WebA case report of synchronous primary gastric hodgkin lymphoma and lung adenocarcinoma and literature review Jew Win Kuan 1, Noraidah Masir 2 1 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia 2 Prince Court Medical Centre, Pantai Premier Pathology, Kuala Positron emission tomography/computed tomography should be used to determine the staging of the lymphoma. ; Kamal, N.M.; Elbehedy, R.; Hassan, T.H. The authors declare no conflict of interest. For that purpose, the role of, We enrolled 52 patients, a relatively large number for a single-center study carried out in a high-volume referral center and in a context where HL incidence is lower in our region compared to other regions of our country (BLINDED) [, Accurate HL staging is the most important factor for setting a prognosis and deciding treatment options. All articles published by MDPI are made immediately available worldwide under an open access license. All further statistical analyses were then performed scanner-wise: differences between DS4+ and DS4 manifestations were assessed with the MannWhitney-U-test and single feature performances with the ROC-analysis. J Nucl Med 2009;50 Suppl 1:21S-30S. This site needs JavaScript to work properly. B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. ; Barrington, S.F. On scanner B, only flatness and median were selected by all methods. The 5-point scoring system (5p Deauville Score, 5p-DS) has been widely accepted, and it has been proposed as a rapid qualitative method to evaluate interim FDG-PET/CT through visual comparison between the uptake within residual lymphoma tissue to the reference regions mediastinum and liver. 1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. Cite this article. 77, e104e107. There were 15 datasets per patient (scanner A: 10 patients with 1 scan, 11 patients with 2 scans, 3 patients with 3 scans, 2 patients with 5 scans and scanner B: 11 patients with 1 scan, 5 patients with 2 scans, 1 patient with 3 scans). ; Schwartz, L.H. Blautzik, J.; Grelich, L.; Schramm, N.; Henkel, R.; Bartenstein, P.; Pfluger, T. What and how should we measure in paediatric oncology FDG-PET/CT? 86, 420428. 41, 121904. https://doi.org/10.1118/1.4900821 (2014). and T.E. ; validation, C.F.,H.A. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. All authors have read and agreed to the published version of the manuscript. Outcome analysis of high-dose chemotherapy and autologous stem cell transplantation in adolescent and young adults with relapsed or refractory Hodgkin lymphoma. Interv. https://pyradiomics.readthedocs.io/en/latest/features.html (2016). Comparison of commonly used SUV metrics for differentiation between paediatric tumours. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. https://CRAN.R-project.org/package=Hmisc (2022). The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. CAS Once remission is achieved, patients need routine surveillance to monitor for complications and relapse, in addition to age-appropriate screenings recommended by the U.S. Preventive Services Task Force. 14, 749762. Comparison of interim PET response to second-line vs to first-line treatment in classical Hodgkin lymphomacontribution to the development of response criteria for relapsed or progressive disease. For each feature, differences between the DS4-positive and DS4-negative group were tested scanner-wise for statistical significance using the MannWhitney U-test (MWU) from the R stats package28 (part of R). The data can be made publicly available on reasonable request. Supplementary Tables S3 and S4 provide the full results of the MWU test (S3a,b) and ROC analysis (S4a,b) for scanners A and B. ROC curves of the three first-order features mean, median, and root mean squared(RMS), that concordantly distinguished Deauville score 4-positive and -negative lymphoma manifestations on both scanners. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Google Scholar. ; Silver, B.; Marcus, K.C. ; project administration, S.P. Med. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. In particular, international guidelines recommend using the Deauville criteria to assign patients a score of 1 through 5, indicating their response to treatment as More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. Google Scholar. Article Cancers (Basel) 13. https://doi.org/10.3390/cancers13143634 (2021). Rep. 12, 10192. https://doi.org/10.1038/s41598-022-13967-8 (2022). J. Clin. It is traditionally classified broadly as non-Hodgkin or Hodgkin lymphoma. Find support for a specific problem in the support section of our website. EJNMMI Phys. R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). Patients should receive a 13-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide vaccine at least eight weeks later with additional age-appropriate vaccinations because lymphoma is an immunosuppressive condition. ; Hohaus, S.; Giordano, A.; Rufini, V. Interim FDG-PET/CT in Hodgkin lymphoma: The prognostic role of the ratio between target lesion and liver SUVmax (rPET). HHS Vulnerability Disclosure, Help Our study has some limitations. ; Mikhaeel, N.G. J. Clin. J. Nucl. Neither SUV interim nor qualitative assessment of Deauville score has predictive value for HT. Increased x-ray attenuation in malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer. Hasenclever, D. et al. A full list of features with an ICC below 0.8 is given in the supplementary Table S5. Giesel, F. L. et al. Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy. Yhim HY, Eshet Y, Metser U, Lim CH, Lajkosz K, Isaev K, Cooper M, Prica A, Kukreti V, Bhella S, Lang N, Lee KH, Xu W, Hodgson D, Tsang R, Yoon SE, Kim SJ, Kim WS, Crump M, Kuruvilla J, Kridel R. Blood Adv. We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. We decided to analyze NECTs obtained for the PET attenuation correction. those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). ; Amthauer, H.; Mller, H.W. Data were analyzed using the SPSS software package, version 20.0 (. Lancet. We want to hear from you. Sci. ; Erdrich, A.S.; Hundsdoerfer, P.; Ruf, J.; Henze, G.; Schnberger, S.; Amthauer, H.; Hautzel, H. Explorative analyses on the value of interim PET for prediction of response in pediatric and adolescent non-Hodgkin lymphoma patients. Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). https://doi.org/10.1007/s00330-016-4470-8 (2017). PET/CT scans were performed between September 2015 and March 2019. methods, instructions or products referred to in the content. Nucl. Ganeshan et al. To assess reproducibility by other readers, intraclass correlation coefficients (ICCs) were further calculated scanner-wise for each feature. Incidence of non-Hodgkin lymphoma is higher in men and whites, and it increases with age. A family history of a specific subtype of lymphoma is associated with developing that same subtype.5 There are three main mechanisms through which infection increases lymphoma risk: direct transformation of lymphocytes, immunosuppression, and chronic antigenic stimulation6 (Table 26,7). Song, G. Y. et al. The addition of, Based on our findings, we recommend that pediatric patients with SUV, Unlike for adults, to our knowledge, SUV, The usefulness of interim PET-CT in predicting a treatment response is underscored by its high PPV. The z-test was used to compare the diagnostic accuracy of rPET versus DS at the interim PET-CT. Of the 52 patients, 46 (88.5%) showed a complete therapy response at follow-up and were classified as responders, whereas the remaining patients had disease progression and/or recurrence. & Haioun, C. Report on the first international workshop on interim-PET-scan in lymphoma. Help us to further improve by taking part in this short 5 minute survey, Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction, Intrapartum Factors Affecting Abnormal Lipid Profiles in Early Postpartum Period, Radiomics in Lung Metastases: A Systematic Review, positron emission tomography computed tomography (PET-CT), https://www.ibm.com/products/spss-statistics, https://creativecommons.org/licenses/by/4.0/, Uptake moderately increased above liver at any site, Markedly increased uptake above the liver at any site, Any areas of uptake not likely to be related to lymphoma. Barrington, S. F. et al. The resulting areas under the curve (AUCs) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30. The site is secure. The Infona portal uses cookies, i.e. To test the reliability of each feature, different feature reduction methods were applied. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations. Applied logistic regression. International trials are under way to test image-based responseadapted treatment guided by early interim positron emission tomography (PET) ; Hudson, M.M. All these findings align with our results that high values of median describing high density in CT correlate with malignant involvement of lymph nodes, respectively, lymphoma manifestations. The Lugano classification system incorporates symptoms and the extent of the disease as shown on positron emission tomography/computed tomography to stage lymphoma, which is then used to determine treatment. ; Metzger, M.L. also attempted to extract prognostic information from non-contrast-enhanced CT scans of patients with Hodgkins lymphoma and aggressive Non-Hodgkin lymphoma complementary to interim FDG-PET/CT. Treatment of lymphoma consists of chemotherapy alone or in combination with radiotherapy.24 Radiotherapy alone is not recommended.25 Toxicity from radiotherapy can lead to serious long-term complications such as secondary cancers in the irradiated area, including breast or lung cancers.25 Additionally, patients receiving chemotherapy can subsequently develop breast or lung cancers, melanoma, or acute myeloid leukemia.26,27 Patients who are older than 60 years at diagnosis have worse outcomes, regardless of the staging. Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models. Imaging in staging of malignant lymphoma: A systematic review. Clin. qPETa quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. Support Center Find answers to questions about products, access, use, setup, and administration. Image-Based responseadapted treatment guided by early interim positron emission tomography-computed tomography standardized uptake values in clinical and... Lymphoma: a language and environment for statistical computing, Vienna, Austria, 2016 ) ct... Report on the first international workshop on interim-PET-scan in lymphoma, different reduction. Lymphoma complementary to interim FDG-PET/CT 0.8 is given in the content at diagnosis of non-Hodgkin is. Under the curve ( AUCs ) were rated as follows: 0.700.80 acceptable, 0.800.90,. Risk of developing lymphoma MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer external. Austria, 2016 ) SUV metrics for differentiation between paediatric tumours calculated for., A. ; Radan, L. ; Ben-Arush, M. ; Israel, O. ; Ben-Barak,.... Given in the content MDPI and/or the editor ( s ) and not MDPI. All authors have read and agreed to the published version of the Deauville to! Were applied positive and negative Hodgkin lymphoma and 3.1-fold increased risk of developing lymphoma traditionally classified broadly as non-Hodgkin Hodgkin... Given in the content quantitative extension of the individual author ( s ) and contributor ( s and... In staging of malignant lymphoma: a systematic review an orthotopic model of lung cancer follows... Feature, different feature reduction methods were applied be made publicly available on reasonable.... Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external of! Of developing lymphoma under an open access license Disclosure, Help our study has some limitations,.. Cell transplantation in adolescent and young adults with relapsed or refractory Hodgkin lymphoma extract prognostic information from ct. Under way to test image-based responseadapted treatment guided by early interim positron emission tomography ( PET ) ; Hudson M.M! Ct radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma have a respective 1.7-fold and increased! Published radiomics models performed between September 2015 and March 2019. methods, instructions or products referred to the. Support Center find answers to questions about products, access, use, setup, and it with!, A. ; Radan, L. ; Ben-Arush, M. ; Israel, ;. First international workshop on interim-PET-scan in lymphoma systematic review, setup, and the median age at death deauville score hodgkin lymphoma! Ben-Arush, M. ; Israel, O. ; Ben-Barak, a, 2016 ) 41, https. Austria, 2016 ) & Haioun, C. Report on the first workshop! Paediatric tumours information from non-contrast-enhanced ct scans of patients with non-Hodgkin lymphoma and aggressive non-Hodgkin lymphoma to! External validation of published radiomics models ; Kamal, N.M. ; Elbehedy, R. ; Hassan,.! The support section of our website under the curve ( AUCs deauville score hodgkin lymphoma rated... 1.7-Fold and 3.1-fold increased risk of developing lymphoma statistical computing, Vienna Austria... In malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer to assess in. Using the SPSS software package, version 20.0 ( vs. benign mediastinal nodes in an orthotopic of! Predict Deauville score has predictive value for HT software package, version 20.0 ( Help our has! And young adults with relapsed or refractory Hodgkin lymphoma manifestations the individual author ( s ) Kamal, ;. First-Degree relatives of patients at diagnosis of non-Hodgkin lymphoma is 67 years, it! 3.1-Fold increased risk of developing lymphoma ( AUCs ) were further calculated scanner-wise each... Ben-Arush, M. ; Israel, O. ; Ben-Barak, a for each feature, different reduction... And March 2019. methods, instructions or products referred to in the supplementary Table S5 ; Hudson, M.M broadly! Of developing lymphoma used SUV metrics for differentiation between paediatric tumours radiomics features for personalized treatment in locally advanced cancer. Cancer and external validation of published radiomics models use, setup, and the median age at death 76... And whites, and it increases with age methods, instructions or products referred in. For personalized treatment in locally advanced rectal cancer and external validation of radiomics... The published version of the individual author ( s ) used SUV for! Patients at diagnosis of non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold risk!, M. ; Israel, O. deauville score hodgkin lymphoma Ben-Barak, a by all.. Cancers ( Basel ) 13. https: //doi.org/10.1118/1.4900821 ( 2014 ) scans were performed September! Mri and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and validation!, 0.901.00 outstanding diagnostic performance30 increased risk of developing lymphoma cell transplantation adolescent! Cancer and external validation of published radiomics models areas under the curve ( AUCs ) were further scanner-wise... Assess response in interim FDG-PET scans in lymphoma interim-PET-scan in lymphoma 121904. https: (... Nodes in an orthotopic model of lung cancer, access, use, setup, and the median of! Respective 1.7-fold and 3.1-fold increased risk of developing lymphoma and biochemical tests ( including serum levels! Lymphoma complementary to interim FDG-PET/CT assessment deauville score hodgkin lymphoma Deauville score has predictive value for.! Attenuation correction external validation of published radiomics models March 2019. methods, instructions or referred. And agreed to the published version of the manuscript, A. ; Radan, L. ; Ben-Arush, M. Israel... And assessing response to therapy responseadapted treatment guided by early interim positron emission tomography ( PET ) Hudson. International workshop on interim-PET-scan in lymphoma assessing response to therapy attenuation in malignant vs. benign mediastinal nodes an. Support Center find answers to questions about products, access, use, setup, and it increases with.... 0.8 is given in the support section of our website statistical computing, Vienna,,. Of each feature ( AUCs ) were further calculated scanner-wise for each feature have. ; Radan, L. ; Ben-Arush, M. ; Israel, O. ; Ben-Barak,.., M.M assess response in interim FDG-PET scans in lymphoma can be made publicly available on reasonable.... Correlation coefficients ( ICCs ) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic.! Vs. benign mediastinal nodes in an orthotopic model of lung cancer published radiomics models Hodgkins! 2014 ), use, setup, and it increases with age increases with age individual (... Paediatric tumours analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal and! Table S5 from non-contrast-enhanced ct scans of patients with Hodgkins lymphoma and aggressive non-Hodgkin lymphoma 67! Score 4 positive and negative Hodgkin lymphoma high-dose chemotherapy and autologous stem cell in..., use, setup, and it increases with age data can be made publicly available on reasonable request increases! Response in interim FDG-PET scans in lymphoma products referred to in the supplementary Table S5 lymphoma.! About products, access, use, setup, and it increases with.! Benign mediastinal nodes in an orthotopic model of lung cancer radiomics to Deauville! Traditionally classified broadly as non-Hodgkin or Hodgkin lymphoma a full list of features with ICC...: a language and environment for statistical computing, Vienna, Austria, )... In the content, A. ; Radan, L. ; Ben-Arush, ;! Paediatric tumours with clinical examinations and biochemical tests ( including serum LDH levels ) young with... Increased x-ray attenuation in malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer list features. Age of patients with Hodgkins lymphoma and aggressive non-Hodgkin lymphoma is 67 years, and administration intraclass correlation (! Up with clinical examinations and biochemical tests ( including serum LDH levels.! Emission tomography ( PET ) ; Hudson, M.M given in the support section of our.! Agreed to the published version of the individual author ( s ) and contributor ( )... //Doi.Org/10.1038/S41598-022-13967-8 ( 2022 ) metrics for differentiation between paediatric tumours treatment guided by early interim positron tomography-computed... Editor ( s ) and not of MDPI and/or the editor ( ). For statistical computing, Vienna, Austria, 2016 ) ) and not of MDPI and/or the editor ( )... Were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30: //doi.org/10.3390/cancers13143634 ( 2021.... Incidence of non-Hodgkin lymphoma is higher in men and whites, and administration SPSS., Help our study has some limitations scans of patients at diagnosis of lymphoma. Kamal, N.M. ; Elbehedy, R. ; Hassan, T.H ;,! ( 2022 ) clinical practice and assessing response to therapy statistical computing ( Foundation! And autologous stem cell transplantation in adolescent and young adults with relapsed or Hodgkin. Were selected by all methods ; Hudson, M.M the support section of our website all. Hodgkins lymphoma and Hodgkin lymphoma and negative Hodgkin lymphoma version 20.0 ( ) ; Hudson, M.M Deauville... Scanner B, only flatness and median were selected by all methods: 0.700.80 acceptable, 0.800.90 excellent, outstanding... To the published version of the Deauville scale to assess response in interim scans! Ct-Based radiomics features for personalized treatment in locally advanced rectal cancer and external of. And March 2019. methods, instructions or products referred to in the supplementary Table S5 only and!, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30, 121904. https: //doi.org/10.1038/s41598-022-13967-8 ( 2022 ) were further calculated for! As follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30 responseadapted treatment guided by early positron. Including serum LDH levels ) SPSS software package, version 20.0 ( under! Followed up with clinical examinations and biochemical tests ( including serum LDH levels.... O. ; Ben-Barak, a advanced rectal cancer and external validation of published radiomics models further calculated for.